Adalimumab

Therapeutic Adalimumab antibody from the original Humira® and biosimilar commercial drugs.

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Product Batch	Antigen	Molecular Class	Drug Brand	Product Concentration	CoA	Quantity per vial	Storage Temperature	Expiry Date	Price from
Adalimumab 1120078A	TNF alpha	Biosimilar , Monoclonal Antibody	Amgevita®	50 mg/mL	–	2 mg	-80°C	12/2021	265,50 €	view product Max: 10 Min: 1 Step: 1
Adalimumab 1163571	TNF alpha	Monoclonal Antibody	Humira®	100 mg/mL	–	4 mg	-80°C	11/2023	438,00 €	view product Max: 10 Min: 1 Step: 1
Adalimumab 1825216	TNF alpha	Biosimilar , Monoclonal Antibody	Hulio®	50 mg/mL	–	2 mg	-80°C	02/2023	265,50 €	view product Max: 10 Min: 1 Step: 1
Adalimumab 1909689A	TNF alpha	Biosimilar , Monoclonal Antibody	Hukyndra®	100 mg/mL	–	2 mg	-80°C	10/2023	344,00 €	view product Max: 10 Min: 1 Step: 1
Adalimumab 28209AS14	TNF alpha	Monoclonal Antibody	Humira®	100 mg/mL	–	4 mg	-80°C	03/2023	394,20 €	view product Max: Min: 1 Step: 1
Adalimumab 2LJPO1T11	TNF alpha	Biosimilar , Monoclonal Antibody	Yuflyma®	100 mg/mL	–	4 mg	-80°C	02/2024	344,00 €	view product Max: 10 Min: 1 Step: 1
Adalimumab 70225XH07	TNF alpha	Monoclonal Antibody	Humira®	100 mg/mL	yes	4 mg	-80°C	09/2018	394,20 €	view product Max: 5 Min: 1 Step: 1
Adalimumab 73254XH03	TNF alpha	Monoclonal Antibody	Humira®	100 mg/mL	yes	4 mg	-80°C	12/2018	394,20 €	view product Max: 10 Min: 1 Step: 1
Adalimumab 76287XH07	TNF alpha	Monoclonal Antibody	Humira®	100 mg/mL	yes	4 mg	-80°C	03/2019	394,20 €	view product Max: 10 Min: 1 Step: 1
Adalimumab 76287XH11	TNF alpha	Monoclonal Antibody	Humira®	100 mg/mL	yes	4 mg	-80°C	03/2019	394,20 €	view product Max: 10 Min: 1 Step: 1
Adalimumab 80315XH04	TNF alpha	Monoclonal Antibody	Humira®	100 mg/mL	yes	4 mg	-80°C	07/2019	394,20 €	view product Max: 10 Min: 1 Step: 1
Adalimumab 85364XH07	TNF alpha	Monoclonal Antibody	Humira®	100 mg/mL	yes	4 mg	-80°C	12/2019	394,20 €	view product Max: 1 Min: 1 Step: 1
Adalimumab 88400XH01	TNF alpha	Monoclonal Antibody	Humira®	100 mg/mL	yes	4 mg	-80°C	03/2020	394,20 €	view product Max: 1 Min: 1 Step: 1
Adalimumab AU034994	TNF alpha	Biosimilar , Monoclonal Antibody	Idacio®	50 mg/mL	–	2 mg	-80°C	10/2023	345,00 €	view product Max: 10 Min: 1 Step: 1
Adalimumab GR226512	TNF alpha	Biosimilar , Monoclonal Antibody	Imraldi®	50 mg/mL	–	2 mg	-80 °C	10/2023	295,00 €	view product Max: 10 Min: 1 Step: 1
Adalimumab MA8208	TNF alpha	Biosimilar , Monoclonal Antibody	Hyrimoz®	50 mg/mL	–	2 mg	-80°C	06/2024	295,00 €	view product Max: 10 Min: 1 Step: 1

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Humira^® / Adalimumab Reference Product

Drug name	Humira®
INN	Adalimumab
API type	Adalimumab is a recombinant human monoclonal antibody expressed in Chinese Hamster Ovary cells.
Pharmacotherapeutic group	Immunosuppressants, Tumour Necrosis Factor alpha (TNF-α) inhibitors.
ATC code	L04AB04
Target of antibody	TNF alpha
General function	Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of0.1-0.2 nM).
Short description
Pharmacodynamic properties (Mechanism of action; Source EMA document)	Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors.
Pharmacodynamic properties (Pharmacodynamic effects; Source EMA document)	Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of 0.1-0.2 nM).
Original license holder	AbbVie Biotechnology GmbH Knollstrasse 67061 Ludwigshafen Germany
Marketing authorisation numbers	EU/1/03/256/022
Marketing authorisation holder	AbbVie Ltd Maidenhead SL6 4UB United Kingdom
Name of the manufacturer of the biological active substance	AbbVie Bioresearch Center 100 Research Drive Worcester MA 01605 USA
Name and address of the manufacturer(s) responsible for batch release	AbbVie Biotechnology GmbH Knollstrasse 67061 Ludwigshafen Germany
Max shelf life	24 months
Storage conditions	2°C – 8°C
List of excipients	Mannitol Polysorbate 80