Romiplostim

Therapeutic Romiplostim fusion protein from the original Nplate® commercial drug.

Reference Standard as Aliquots

Nplate®
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2023.02
Orencia®
LT
44,60  /mg
Select quantity:
Max: 50
Min: 10
Step: 5
Max: 50
Min: 10
Step: 5
mg
2025.05
Humira®
DE
112,50  /mg
Max: 4
Min: 1
Step: 1
mg
2018.09
Humira®
DE
113,00  /mg
Select quantity:
Max: 16
Min: 4
Step: 4
Max: 16
Min: 4
Step: 4
mg
2018.12
Humira®
LV
113,00  /mg
Select quantity:
Max: 40
Min: 4
Step: 4
Max: 40
Min: 4
Step: 4
mg
2019.03
Humira®
DE
113,00  /mg
Select quantity:
Max: 40
Min: 4
Step: 4
Max: 40
Min: 4
Step: 4
mg
2019.03
Humira®
DE
113,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 4
Max: 20
Min: 4
Step: 4
mg
2019.07
Humira®
LV
113,00  /mg
Select quantity:
Max: 32
Min: 4
Step: 4
Max: 32
Min: 4
Step: 4
mg
Date to be defined
Eylea®
DE
1.302,00  /mg
Select quantity:
Max:
Min: 1
Step: 1
Max:
Min: 1
Step: 1
mg
2023.01
Idelvion®
DE
20,80  /mg
Select quantity:
Max: 125
Min: 25
Step: 25
Max: 125
Min: 25
Step: 25
mg
2024.07
Proleukin®
DE
347,00  /mg
Select quantity:
Max: 3
Min: 1
Step: 1
Max: 3
Min: 1
Step: 1
mg
2026.01
Proleukin®
DE
260,00 /mg
Max: 19
Min: 1
Step: 1
mg
2026.08
Lemtrada®
DE
1.862,00 /mg
Max: 20
Min: 1
Step: 1
mg
2025.12
Myozyme®
DE
84,00 /mg
Max: 315
Min: 1
Step: 1
mg
Date to be defined
Praluent®
DE
36,00  /mg
Select quantity:
Max:
Min: 60
Step: 6
Max:
Min: 60
Step: 6
mg
2023.02
Actilyse®
DE
264,00  /mg
Select quantity:
Max: 10
Min: 1
Step: 1
Max: 10
Min: 1
Step: 1
mg
2027.04
Rybrevant®
DE
40,00 /mg
Max: 50
Min: 1
Step: 1
mg
2026.11
Saphnelo®
DE
333,00  /mg
Select quantity:
Max: 41
Min: 1
Step: 1
Max: 41
Min: 1
Step: 1
mg
2022.03
Tecentriq®
LT
30,00  /mg
Select quantity:
Max: 120
Min: 24
Step: 12
Max: 120
Min: 24
Step: 12
mg
05/2026
Nexviadyme®
DE
1.099,00  /mg
Select quantity:
Max: 18
Min: 1
Step: 1
Max: 18
Min: 1
Step: 1
mg
2021.01
Bavencio®
DE
72,00  /mg
Select quantity:
Max: 20
Min: 6
Step: 2
Max: 20
Min: 6
Step: 2
mg
2025.01
Nulojix®
37,00 /mg
Max: 180
Min: 1
Step: 1
mg
Date to be defined
Benlysta®
DE
59,00  /mg
Select quantity:
Max:
Min: 32
Step: 4
Max:
Min: 32
Step: 4
mg
Date to be defined
Fasenra®
DE
504,00  /mg
Select quantity:
Max:
Min: 9
Step: 1
Max:
Min: 9
Step: 1
mg
2018.06
Avastin®
DE
106,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2018.09
Avastin®
DE
106,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2018.09
Avastin®
DE
106,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2018.12
Avastin®
DE
106,00  /mg
Max: 20
Min: 4
Step: 2
mg
2019.03
Avastin®
DE
106,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2019.08
Avastin®
LV
106,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2019.10
Avastin®
DE
106,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2021.03
Avastin®
LT
106,00  /mg
Select quantity:
Max: 12
Min: 4
Step: 2
Max: 12
Min: 4
Step: 2
mg
2017.09
Avastin®
DE
89,00  /mg
Select quantity:
Max: 30
Min: 6
Step: 3
Max: 30
Min: 6
Step: 3
mg
2018.03
Avastin®
DE
89,00  /mg
Select quantity:
Max: 30
Min: 6
Step: 3
Max: 30
Min: 6
Step: 3
mg
2024.07
Avastin®
LT
106,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2027.03
Avastin®
DE
212,00  /mg
Select quantity:
Max: 41
Min: 1
Step: 1
Max: 41
Min: 1
Step: 1
mg
Date to be defined
Zinplava®
DE
254,00  /mg
Select quantity:
Max:
Min: 16
Step: 2
Max:
Min: 16
Step: 2
mg
Date to be defined
Bimzelx®
DE
73,00  /mg
Select quantity:
Max:
Min: 64
Step: 8
Max:
Min: 64
Step: 8
mg
2027.07
Blincyto®
CH
788,00 /mg
Max: 8
Min: 1
Step: 1
mg
2027.09
Adcetris®
DE
370,00 /mg
Max: 50
Min: 1
Step: 1
mg
2022.05
Kyntheum®
DE
42,14  /mg
Select quantity:
Max: 70
Min: 14
Step: 7
Max: 70
Min: 14
Step: 7
mg
Date to be defined
Beovu®
DE
276,00  /mg
Select quantity:
Max:
Min: 9,9
Step: 3
Max:
Min: 9,9
Step: 3
mg
Date to be defined
Crysvita®
DE
1.442,00  /mg
Select quantity:
Max:
Min: 5
Step: 1
Max:
Min: 5
Step: 1
mg
2025.07
Ilaris®
DE
1.884,00 /mg
Max: 21
Min: 1
Step: 1
mg
2025.07
Ilaris®
DE
1.884,00 /mg
Max: 23
Min: 1
Step: 1
mg
Date to be defined
Libtayo®
DE
118,00  /mg
Select quantity:
Max:
Min: 50
Step: 5
Max:
Min: 50
Step: 5
mg
2022.09
Cimzia®
DE
34,25  /mg
Select quantity:
Max: 72
Min: 16
Step: 8
Max: 72
Min: 16
Step: 8
mg
2025.03
Cimzia®
DE
26,00 /mg
Max: 256
Min: 1
Step: 1
mg
2019.11
Erbitux®
DE
98,50  /mg
Select quantity:
Max: 20
Min: 6
Step: 2
Max: 20
Min: 6
Step: 2
mg
2020.01
Erbitux®
DE
98,50  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2021.05
Erbitux®
DE
98,50  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2021.09
Erbitux®
DE
65,80  /mg
Select quantity:
Max: 50
Min: 5
Step: 5
Max: 50
Min: 5
Step: 5
mg
2021.11
Erbitux®
DE
98,50  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
Date to be defined
Adakveo®
DE
167,00  /mg
Select quantity:
Max:
Min: 18
Step: 2
Max:
Min: 18
Step: 2
mg
2018.11
Darzalex®
DE
121,00  /mg
Select quantity:
Max: 6
Min: 4
Step: 2
Max: 6
Min: 4
Step: 2
mg
2019.05
Darzalex®
DE
121,00  /mg
Select quantity:
Max: 34
Min: 4
Step: 4
Max: 34
Min: 4
Step: 4
mg
2023.11
Darzalex®
DE
88,50  /mg
Select quantity:
Max: 12
Min: 4
Step: 4
Max: 12
Min: 4
Step: 4
mg
2024.11
Darzalex®
DE
88,50  /mg
Select quantity:
Max: 40
Min: 4
Step: 4
Max: 40
Min: 4
Step: 4
mg
2018.01
Darzalex®
DE
121,00  /mg
Select quantity:
Max: 24
Min: 4
Step: 4
Max: 24
Min: 4
Step: 4
mg
2018.04
Darzalex®
DE
101,30  /mg
Select quantity:
Max: 30
Min: 6
Step: 3
Max: 30
Min: 6
Step: 3
mg
2019.09
Darzalex®
DE
121,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2021.01
Darzalex®
DE
121,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2023.07
Darzalex®
DE
121,00  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
Date to be defined
Xgeva®
DE
81,00  /mg
Select quantity:
Max:
Min: 27
Step: 3
Max:
Min: 27
Step: 3
mg
2018.11
Prolia®
DE
108,00  /mg
Select quantity:
Max: 12
Min: 3
Step: 3
Max: 12
Min: 3
Step: 3
mg
2019.07
Prolia®
DE
108,00  /mg
Select quantity:
Max: 30
Min: 3
Step: 3
Max: 30
Min: 3
Step: 3
mg
2019.10
Prolia®
DE
108,00  /mg
Select quantity:
Max: 15
Min: 3
Step: 3
Max: 15
Min: 3
Step: 3
mg
2020.04
Prolia®
DE
108,00  /mg
Select quantity:
Max: 21
Min: 3
Step: 3
Max: 21
Min: 3
Step: 3
mg
2020.09
Prolia®
DE
108,00  /mg
Select quantity:
Max: 6
Min: 3
Step: 3
Max: 6
Min: 3
Step: 3
mg
2021.01
Prolia®
DE
108,00  /mg
Select quantity:
Max: 6
Min: 3
Step: 3
Max: 6
Min: 3
Step: 3
mg
2022.06
Prolia®
DE
108,00  /mg
Select quantity:
Max: 30
Min: 3
Step: 3
Max: 30
Min: 3
Step: 3
mg
2022.10
Prolia®
DE
108,00  /mg
Select quantity:
Max: 15
Min: 3
Step: 3
Max: 15
Min: 3
Step: 3
mg
2023.12
Pulmozyme®
DE
188,00  /mg
Select quantity:
Max: 3
Min: 1
Step: 1
Max: 3
Min: 1
Step: 1
mg
2025.07
Jemperli®
DE
38,00 /mg
Max: 500
Min: 1
Step: 1
mg
2025.10
Jemperli®
IT
105,00 /mg
Max: 430
Min: 1
Step: 1
mg
2025.10
Jemperli®
CH
86,00 /mg
Max: 430
Min: 1
Step: 1
mg
2026.03
Jemperli®
USA
180,00 /mg
Max: 430
Min: 1
Step: 1
mg
2023.07
Trulicity®
DE
319,00  /mg
Select quantity:
Max: 10
Min: 1
Step: 1
Max: 10
Min: 1
Step: 1
mg
2024.04
Trulicity®
DE
319,00  /mg
Select quantity:
Max: 12
Min: 1
Step: 1
Max: 12
Min: 1
Step: 1
mg
2023.12
Trulicity®
DE
319,00  /mg
Select quantity:
Max: 16
Min: 1
Step: 1
Max: 16
Min: 1
Step: 1
mg
2024.11
Dupixent®
LT
32,17  /mg
Select quantity:
Max: 120
Min: 12
Step: 12
Max: 120
Min: 12
Step: 12
mg
2021.10
Imfinzi®
DE
109,00  /mg
Select quantity:
Max: 6
Min: 4
Step: 2
Max: 6
Min: 4
Step: 2
mg
2022.04
Soliris®
LT
186,75  /mg
Select quantity:
Max: 40
Min: 4
Step: 4
Max: 40
Min: 4
Step: 4
mg
Date to be defined
Vyvgart®
DE
808,00  /mg
Select quantity:
Max:
Min: 70
Step: 5
Max:
Min: 70
Step: 5
mg
2026.10
Empliciti®
DE
33,00 /mg
Max: 110
Min: 1
Step: 1
mg
2022.09
Empliciti®
DE
49,33  /mg
Select quantity:
Max: 60
Min: 12
Step: 6
Max: 60
Min: 12
Step: 6
mg
2024.02
Empliciti®
DE
49,33  /mg
Select quantity:
Max: 60
Min: 12
Step: 6
Max: 60
Min: 12
Step: 6
mg
2026.08
Padcev®
DE
259,00 /mg
Max: 2
Min: 1
Step: 1
mg
2026.12
Padcev®
DE
259,00 /mg
Max: 5
Min: 1
Step: 1
mg
Date to be defined
Vyepti®
DE
106,00  /mg
Select quantity:
Max:
Min: 30
Step: 5
Max:
Min: 30
Step: 5
mg
Date to be defined
Aimovig®
DE
70,00  /mg
Select quantity:
Max:
Min: 31,5
Step: 3
Max:
Min: 31,5
Step: 3
mg
2024.01
Enbrel®
DE
43,17  /mg
Select quantity:
Max: 60
Min: 12
Step: 6
Max: 60
Min: 12
Step: 6
mg
2019.02
Enbrel®
DE
58,50  /mg
Select quantity:
Max: 40
Min: 8
Step: 4
Max: 40
Min: 8
Step: 4
mg
2019.04
Enbrel®
DE
98,50  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2019.06
Enbrel®
DE
98,50  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2019.08
Enbrel®
DE
98,50  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2019.12
Enbrel®
DE
58,50  /mg
Select quantity:
Max: 40
Min: 8
Step: 4
Max: 40
Min: 8
Step: 4
mg
2019.10
Enbrel®
DE
98,50  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2020.04
Enbrel®
DE
98,50  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
Date to be defined
Evkeeza®
DE
1.088,00  /mg
Select quantity:
Max:
Min: 8
Step: 1
Max:
Min: 8
Step: 1
mg
2025.06
Repatha®
DE
122,00 /mg
Max: 203
Min: 1
Step: 1
mg
1 2 3

Biosimilars as Aliquots​

Filters Sort results
Reset Apply
Product batch
Expiry date
Brand & Origin
Price
1. Select quantity range
2. Your quantity
2021.12
Amgevita®
DE
152,00  /mg
Select quantity:
Max: 20
Min: 2
Step: 2
Max: 20
Min: 2
Step: 2
mg
2023.02
Hulio®
DE
152,00  /mg
Select quantity:
Max: 20
Min: 2
Step: 2
Max: 20
Min: 2
Step: 2
mg
2023.10
Hukyndra®
DE
152,00  /mg
Select quantity:
Max: 20
Min: 2
Step: 2
Max: 20
Min: 2
Step: 2
mg
2024.02
Yuflyma®
DE
354,00  /mg
Select quantity:
Max: 10
Min: 1
Step: 1
Max: 10
Min: 1
Step: 1
mg
2024.02
Yuflyma®
DE
88,50  /mg
Select quantity:
Max: 40
Min: 4
Step: 4
Max: 40
Min: 4
Step: 4
mg
2023.10
Idacio®
DE
177,50  /mg
Select quantity:
Max: 20
Min: 2
Step: 2
Max: 20
Min: 2
Step: 2
mg
2023.10
Imraldi®
DE
152,00  /mg
Select quantity:
Max: 20
Min: 2
Step: 2
Max: 20
Min: 2
Step: 2
mg
2024.06
Hyrimoz®
DE
152,00  /mg
Select quantity:
Max: 20
Min: 2
Step: 2
Max: 20
Min: 2
Step: 2
mg
Date to be defined
Abevmy®
DE
102,00  /mg
Select quantity:
Max:
Min: 1
Step: 1
Max:
Min: 1
Step: 1
mg
Date to be defined
Aybintio®
DE
102,00  /mg
Select quantity:
Max:
Min: 20
Step: 2
Max:
Min: 20
Step: 2
mg
Date to be defined
Vegzelma®
DE
102,00  /mg
Select quantity:
Max:
Min: 1
Step: 1
Max:
Min: 1
Step: 1
mg
Date to be defined
Aybintio®
102,00  /mg
Select quantity:
Max:
Min: 11
Step: 1
Max:
Min: 11
Step: 1
mg
Date to be defined
Abevmy®
107,00  /mg
Select quantity:
Max:
Min: 11
Step: 1
Max:
Min: 11
Step: 1
mg
Date to be defined
Vegzelma®
102,00  /mg
Select quantity:
Max:
Min: 11
Step: 1
Max:
Min: 11
Step: 1
mg
Date to be defined
Epysqli®
DE
137,00  /mg
Select quantity:
Max:
Min: 48
Step: 3
Max:
Min: 48
Step: 3
mg
Date to be defined
Epysqli®
DE
137,00  /mg
Select quantity:
Max: 20
Min: 16
Step: 1
Max: 20
Min: 16
Step: 1
mg
2022.08
Silapo®
DE
0,08  /mg
Select quantity:
Max: 45000
Min: 5000
Step: 5000
Max: 45000
Min: 5000
Step: 5000
mg
2023.04
Erelzi®
DE
68,00  /mg
Select quantity:
Max: 40
Min: 8
Step: 4
Max: 40
Min: 8
Step: 4
mg
2023.11
Benepali®
DE
68,00  /mg
Select quantity:
Max: 27
Min: 1
Step: 1
Max: 27
Min: 1
Step: 1
mg
2023.08
Nepexto®
DE
68,00  /mg
Select quantity:
Max: 40
Min: 8
Step: 4
Max: 40
Min: 8
Step: 4
mg
Date to be defined
Remsima®
DE
120,00  /mg
Select quantity:
Max:
Min: 20
Step: 2
Max:
Min: 20
Step: 2
mg
2025.01
Flixabi®
DE
119,50  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
2027.03
Inflectra®
90,00 /mg
Max: 78
Min: 1
Step: 1
mg
2022.10
Zessly®
DE
120,50  /mg
Select quantity:
Max: 20
Min: 4
Step: 2
Max: 20
Min: 4
Step: 2
mg
Date to be defined
Ranivisio®
621,00  /mg
Select quantity:
Max: 10
Min: 5
Step: 1
Max: 10
Min: 5
Step: 1
mg
Date to be defined
Ximluci®
680,00  /mg
Select quantity:
Max: 10
Min: 5
Step: 1
Max: 10
Min: 5
Step: 1
mg
Date to be defined
Byooviz®
621,00  /mg
Select quantity:
Max: 10
Min: 5
Step: 1
Max: 10
Min: 5
Step: 1
mg
Date to be defined
Truxima®
117,00  /mg
Select quantity:
Max:
Min: 10
Step: 1
Max:
Min: 10
Step: 1
mg
2025.12
Ruxience®
DE
76,00 /mg
Max: 80
Min: 1
Step: 1
mg
2025.12
Ruxience®
DE
202,00  /mg
Select quantity:
Max: 40
Min: 1
Step: 1
Max: 40
Min: 1
Step: 1
mg
2026.03
Rixathon®
DE
92,00 /mg
Max: 74
Min: 1
Step: 1
mg
Date to be defined
Max:
Min: 1
Step: 1
mg
Date to be defined
Ontruzant®
DE
62,00  /mg
Select quantity:
Max:
Min: 42,042
Step: 6
Max:
Min: 42,042
Step: 6
mg
Date to be defined
Ontruzant®
62,00  /mg
Select quantity:
Max:
Min: 15
Step: 1
Max:
Min: 15
Step: 1
mg
2025.01
Kanjinti®
DE
61,17  /mg
Select quantity:
Max: 60
Min: 6
Step: 6
Max: 60
Min: 6
Step: 6
mg
2026.08
Zercepac®
DE
52,00 /mg
Max: 90
Min: 1
Step: 1
mg
2025.10
Ogivri®
DE
56,00 /mg
Max: 72
Min: 1
Step: 1
mg
2026.09
Trazimera®
DE
61,00 /mg
Max: 110
Min: 1
Step: 1
mg

Batch specific analytical data available

Evidentic’s analytical service includes a comprehensive array of methods to support the drug development process, including, for example, structure, aggregation, degree of isomerization and N-glycans identification of the active pharmaceutical ingredient (API). ​

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Product Information

Here you will find the product information for the reference product.

NPlate® / Romiplostim Reference Product

Drug nameNplate®
INNRomiplostim
API typeFc-peptide fusion protein (peptibody)
Pharmacotherapeutic group
Antihaemorrhagics, other systemic haemostatics
ATC code
B02BX04
Target of antibody
TPO receptor (also known as cMpl)
General functionRomoplostim is indicated for the treatment of primary immune thrombocytopenia (ITP) in adult patients who are refractory to other treatments (e.g. corticosteroids, immunoglobulins). Nplate is indicated for the treatment of chronic primary immune thrombocytopenia (ITP) in paediatric patients one year of age and older who are refractory to other treatments (e.g. corticosteroids, immunoglobulins)
Short description
Pharmacodynamic properties
(Mechanism of action; Source EMA document)
Romiplostim is an Fc-peptide fusion protein (peptibody) that signals and activates intracellular transcriptional pathways via the TPO receptor (also known as cMpl) to increase platelet production. The peptibody molecule is comprised of a human immunoglobulin IgG1 Fc domain, with each single-chain subunit covalently linked at the C-terminus to a peptide chain containing 2 TPO receptor-binding domains. Romiplostim has no amino acid sequence homology to endogenous TPO. In pre-clinical and clinical trials no anti-romiplostim antibodies cross reacted with endogenous TPO.

The pharmacokinetics of romiplostim involved target-mediated disposition, which is presumably mediated by TPO receptors on platelets and other cells of the thrombopoietic lineage such as megakaryocytes.
Pharmacodynamic properties (Pharmacodynamic effects; Source EMA document)The pharmacokinetics of romiplostim involved target-mediated disposition, which is presumably mediated by TPO receptors on platelets and other cells of the thrombopoietic lineage such as megakaryocytes.

Due to the formation of neutralising antibodies pharmacodynamic effects of romiplostim in rats were often decreasing at prolonged duration of administration. Toxicokinetic studies showed no interaction of the antibodies with the measured concentrations.
Original license holder
Amgen Europe B.V.
Marketing authorisation numbers
EU/1/08/497/001
Marketing authorisation holder
Amgen Europe B.V. Minervum 7061 4817 ZK Breda The Netherlands
Name of the manufacturer of the biological active substance
Amgen Inc One Amgen Center Drive Thousand Oaks, CA 91320 USA
Name and address of the manufacturer(s) responsible for batch releaseAmgen Europe B.V. Minervum 7061 NL-4817 ZK Breda The Netherlands
Max shelf life
3 years
Storage conditions
2°C – 8°C
List of excipients
Mannitol (E421), Sucrose, L-histidine, Hydrochloric acid (for pH adjustment), Polysorbate 20

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