Therapeutic Eptinezumab antibody from the original Vyepti® commercial drug.
Product batch | Expiry date | Brand & Origin | Price | 1. Select quantity range | 2. Your quantity | |
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Date to be defined |
Vyepti® DE |
106,00 €
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Evidentic’s analytical service includes a comprehensive array of methods to support the drug development process, including, for example, structure, aggregation, degree of isomerization and N-glycans identification of the active pharmaceutical ingredient (API).
Here you will find the product information for the reference product.
Drug name | Vyepti® |
INN | Eptinezumab |
API type | Eptinezumab is a humanized monoclonal antibody produced in Pichia pastoris yeast cells. |
Pharmacotherapeutic group | analgesics, calcitonin gene-related peptide (CGRP) antagonists |
ATC code | N02CD05 |
Target of antibody | α- and β- CGPR |
General function | |
Short description | |
Pharmacodynamic properties (Mechanism of action; Source EMA document) | Eptinezumab is a recombinant humanized immunoglobulin G1 (IgG1) antibody that binds to α- and βforms of human calcitonin gene-related peptide (CGRP) ligand with low picomolar affinity (4 and 3 pM Kd, respectively). Eptinezumab prevents the activation of the CGRP receptors and hence the downstream cascade of physiological events linked to initiation of migraine attacks. Eptinezumab inhibits α and β- CGRP-mediated neurogenic inflammation and vasodilation. Eptinezumab is highly selective (>100 000-fold vs related neuropeptides amylin, calcitonin, adrenomedullin and intermedin). |
Pharmacodynamic properties (Pharmacodynamic effects; Source EMA document) | |
Original license holder | |
Marketing authorisation numbers | EU/1/21/1599/001 EU/1/21/1599/002 EU/1/21/1599/003 |
Marketing authorisation holder | H. Lundbeck A/S Ottiliavej 9 2500 Valby Denmark |
Name of the manufacturer of the biological active substance | Novartis Pharmaceutical Manufacturing GmbH Biochemiestrasse 10 6250 Kundl Austria |
Name and address of the manufacturer(s) responsible for batch release | H. Lundbeck A/S Ottiliavej 9 2500 Valby Denmark |
Max shelf life | 36 months |
Storage conditions | 2°C – 8°C |
List of excipients | Sorbitol (E420) L-histidine L-histidine hydrochloride monohydrate Polysorbate 80 Water for injections |
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