Therapeutic Eptinezumab antibody from the original Vyepti® commercial drug.
Product batch
| Expiry date
| Brand & Origin
| Price
| 1. Select quantity range | 2. Your quantity | |
|---|---|---|---|---|---|---|
Date to be defined |
Vyepti® DE |
106,00 €
/mg
|
Select quantity:
|
mg |
Evidentic’s analytical service includes a comprehensive array of methods to support the drug development process, including, for example, structure, aggregation, degree of isomerization and N-glycans identification of the active pharmaceutical ingredient (API).
Here you will find the product information for the reference product.
| Drug name | Vyepti® |
| INN | Eptinezumab |
| API type | Eptinezumab is a humanized monoclonal antibody produced in Pichia pastoris yeast cells. |
| Pharmacotherapeutic group | analgesics, calcitonin gene-related peptide (CGRP) antagonists |
| ATC code | N02CD05 |
| Target of antibody | α- and β- CGPR |
| General function | |
| Short description | |
| Pharmacodynamic properties (Mechanism of action; Source EMA document) | Eptinezumab is a recombinant humanized immunoglobulin G1 (IgG1) antibody that binds to α- and βforms of human calcitonin gene-related peptide (CGRP) ligand with low picomolar affinity (4 and 3 pM Kd, respectively). Eptinezumab prevents the activation of the CGRP receptors and hence the downstream cascade of physiological events linked to initiation of migraine attacks. Eptinezumab inhibits α and β- CGRP-mediated neurogenic inflammation and vasodilation. Eptinezumab is highly selective (>100 000-fold vs related neuropeptides amylin, calcitonin, adrenomedullin and intermedin). |
| Pharmacodynamic properties (Pharmacodynamic effects; Source EMA document) | |
| Original license holder | |
| Marketing authorisation numbers | EU/1/21/1599/001 EU/1/21/1599/002 EU/1/21/1599/003 |
| Marketing authorisation holder | H. Lundbeck A/S Ottiliavej 9 2500 Valby Denmark |
| Name of the manufacturer of the biological active substance | Novartis Pharmaceutical Manufacturing GmbH Biochemiestrasse 10 6250 Kundl Austria |
| Name and address of the manufacturer(s) responsible for batch release | H. Lundbeck A/S Ottiliavej 9 2500 Valby Denmark |
| Max shelf life | 36 months |
| Storage conditions | 2°C – 8°C |
| List of excipients | Sorbitol (E420) L-histidine L-histidine hydrochloride monohydrate Polysorbate 80 Water for injections |
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