Alemtuzumab
Therapeutic Alemtuzumab antibody from the original Lemtrada® commercial drug.
Reference Standard as Aliquots
Lemtrada®
Filters
Sort results
Reset
Apply
Product Batch | Therapeutic Expiry Date
| Brand & Origin
| Amount per Aliquot
| Select Quantity | Discount | Price per Aliquot
| |
|---|---|---|---|---|---|---|---|
2026.08 |
Lemtrada® DE |
0.5 mg |
Unit: aliquot(s) |
1.519,00 €/aliquot
|
Biosimilars as Aliquots
Access Batch Specific Analytical Information
Evidentic’s Analytical Data Service includes a comprehensive array of methods to support the drug development process, including structure, aggregation, degree of isomerization, and N-glycans identification of the active pharmaceutical ingredient (API).
Product Information
Here you will find the product information for the reference product.
Lemtrada® / Alemtuzumab Reference Product
| Drug name | Lemtrada® |
| INN | Alemtuzumab |
| API type | Alemtuzumab is a monoclonal antibody produced in mammalian cell (Chinese Hamster Ovary) suspension culture in a nutrient medium by recombinant DNA technology. |
| Pharmacotherapeutic group | Selective immunosuppressants |
| ATC code | L04AA34 |
| Target of antibody | CD52 |
| General function | Alemtuzumab binds to CD52, a cell surface antigen present at high levels on T (CD3+) and B (CD19+) lymphocytes, and at lower levels on natural killer cells, monocytes, and macrophages. There is little or no CD52 detected on neutrophils, plasma cells, or bone marrow stem cells. Alemtuzumab acts through antibody-dependent cellular cytolysis and complement-mediated lysis following cell surface binding to Tand B lymphocytes. |
| Short description | |
| Pharmacodynamic properties (Mechanism of action; Source EMA document) | Alemtuzumab, is a recombinant DNA-derived humanised monoclonal antibody directed against the 21-28 kD cell surface glycoprotein CD52. Alemtuzumab is an IgG1 kappa antibody with human variable framework and constant regions, and complementary-determining regions from a murine (rat) monoclonal antibody. The antibody has an approximate molecular weight of 150 kD. |
| Pharmacodynamic properties (Pharmacodynamic effects; Source EMA document) | Alemtuzumab depletes circulating T and B lymphocytes after each treatment course with the lowest observed values occurring 1 month after a course of treatment (the earliest post-treatment time point in phase 3 studies). Lymphocytes repopulate over time with B-cell recovery usually completed within 6 months. CD3+ and CD4+ lymphocyte counts rise more slowly towards normal, but generally do not return to baseline by 12-months post-treatment. Approximately 40% of patients had total lymphocyte counts reaching the lower limit of normal (LLN) by 6 months after each treatment course, and approximately 80% of patients had total lymphocyte counts reaching the LLN by 12 months after each course. |
| Original license holder | Sanofi Belgium Leonardo Da Vincilaan 19 B-1831 Diegem Belgium |
| Marketing authorisation numbers | EU/1/13/869/001 |
| Marketing authorisation holder | Sanofi Belgium Leonardo Da Vincilaan 19 B-1831 Diegem Belgium |
| Name of the manufacturer of the biological active substance | Boehringer Ingelheim Pharma GmbH & Co. KG Birkendorfer Straße 65 88397 Biberach an der Riss GERMANY |
| Name and address of the manufacturer(s) responsible for batch release | Genzyme Ireland Limited IDA Industrial Park Old Kilmeaden Road Waterford Ireland |
| Max shelf life | 3 years |
| Storage conditions | 2°C – 8°C |
| List of excipients | Disodium phosphate dihydrate (E339) Disodium edetate Potassium chloride (E508) Potassium dihydrogen phosphate (E340) Polysorbate 80 (E433) Sodium chloride Water for injections |
Support
Do you have a question about the product? Reach out to our team using the form below – we’d be happy to help you!
Ready to simplify your sourcing?
Here’s how to get started:
Select Your Licensed Molecules
Browse our shop and choose the licensed molecule(s) you need. Don’t worry if you can’t find the molecule you’re looking for – we can source it for you!
Get a Quote
Receive a confidential, non-binding quote for the molecule(s) you choose.
Get Qualified & We Deliver
Complete our quick qualification process, place your order, and we’ll ship your molecule(s) within days.
Do you have a question you'd like to ask us?
Here’s how to get started:
