Adalimumab Biosimilar Drug Aliquot | Anti-TNF-α | Therapeutic Antibody

Aliquoted from the biosimilar drug | Now available for research use

Aliquots of the biosimilar Adalimumab (Amgevita®) are now available as research consumables.

Adalimumab biosimilar drug aliquots can be used for in vitro or in vivo experiments. Several other reference drugs are also available. The drug aliquots are generated by aliquoting (dividing and repackaging) the EU-licensed reference drug.

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Amgevita® / Adalimimab Biosimilar Drug

Drug nameAmgevita®
INNAdalimimab biosimilar
API typeAdalimumab is a biosimilar medicinal product. Is a recombinant human monoclonal antibody produced in Chinese Hamster Ovary cells.
Pharmacotherapeutic groupImmunosuppressants, Tumour Necrosis Factor alpha (TNFα) inhibitors
ATC codeL04AB04
Target of antibodyTNFα
General functionAdalimumab is indicated for the treatment of moderate to severe, active rheumatoid arthritis in adult patients when the response to disease-modifying anti-rheumatic drugs including methotrexate has been inadequate. Also indicate for the treatment of severe, active and progressive rheumatoid arthritis in adults not previously treated with methotrexate.
Short description
Pharmacodynamic properties
(Mechanism of action; Source EMA document)
Adalimumab binds specifically to TNF and neutralises the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration.
Pharmacodynamic properties (Pharmacodynamic effects; Source EMA document)After treatment with adalimumab, a rapid decrease in levels of acute phase reactants of inflammation (C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)) and serum cytokines (IL-6) was observed, compared to baseline in patients with rheumatoid arthritis. Serum levels of matrix metalloproteinases (MMP-1 and MMP-3) that produce tissue remodelling responsible for cartilage destruction were also decreased after adalimumab administration.
Original license holder
Marketing authorisation numbersEU/1/07/432/044
Marketing authorisation holderAmgen Europe B.V. Minervum 7061 NL-4817 ZK Breda The Netherlands
Name of the manufacturer of the biological active substanceAmgen Inc One Amgen Center Drive Thousand Oaks, California 91320 United States; Immunex Rhode Island Corporation 40 Technology Way West Greenwich Rhode Island, 02817 United States
Name and address of the manufacturer(s) responsible for batch releaseAmgen Europe B.V. Minervum 7061 4817 ZK Breda The Netherlands; Amgen Technology Ireland UC Pottery Road Dun Laoghaire, Co Dublin Ireland; Amgen NV Telecomlaan 5-7 1831 Diegem Belgium
Max shelf life2 years
Storage conditions2°C – 8°C
List of excipientsGlacial acetic acid- Sucrose Polysorbate 80 - Sodium hydroxide (for pH adjustment) - Water for injections

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Evidentic offers multiple batches of original drug aliquots in low binding Eppendorf tubes for research use only. We provide licence-free drug aliquots with long, short or even “negative shelf life” by storing the products at recommended temperatures (either 2-8°C or -80°C) and ensuring fully functional molecules for research purposes.

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