Adalimumab Biosimilar Drug Aliquot | Anti-TNF-α | Therapeutic Antibody

Aliquoted from the biosimilar drug | Now available for research use

Aliquots of the biosimilar Adalimumab (Yuflyma®) are now available as research consumables.

Adalimumab biosimilar drug aliquots can be used for in vitro or in vivo experiments. Several other reference drugs are also available. The drug aliquots are generated by aliquoting (dividing and repackaging) the EU-licensed reference drug.

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Yuflyma® / Adalimimab Biosimilar Drug

Drug nameYuflyma®
INNAdalimimab biosimilar
API typeAdalimumab is a biosimilar medicinal product. Is a recombinant human monoclonal antibody produced in Chinese Hamster Ovary cells.
Pharmacotherapeutic groupImmunosuppressants, Tumour Necrosis Factor alpha (TNFα) inhibitors
ATC codeL04AB04
Target of antibodyTNFα
General functionAdalimumab is indicated for the treatment of moderate to severe, active rheumatoid arthritis in adult patients when the response to disease-modifying anti-rheumatic drugs including methotrexate has been inadequate. Also indicate for the treatment of severe, active and progressive rheumatoid arthritis in adults not previously treated with methotrexate.
Short description
Pharmacodynamic properties
(Mechanism of action; Source EMA document)
Adalimumab binds specifically to TNF and neutralises the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration.
Pharmacodynamic properties (Pharmacodynamic effects; Source EMA document)After treatment with adalimumab, a rapid decrease in levels of acute phase reactants of inflammation (C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)) and serum cytokines (IL-6) was observed, compared to baseline in patients with rheumatoid arthritis. Serum levels of matrix metalloproteinases (MMP-1 and MMP-3) that produce tissue remodelling responsible for cartilage destruction were also decreased after adalimumab administration.
Original license holder
Marketing authorisation numbersEU/1/20/1513/001-012
Marketing authorisation holderCelltrion Healthcare Hungary Kft.
1062 Budapest
Váci út 1-3. WestEnd Office Building B torony
Hungary
Name of the manufacturer of the biological active substanceCELLTRION INC.
20 Academy-ro 51 beon-gil
Yeonsu-gu
22014 Incheon
Republic of Korea
Name and address of the manufacturer(s) responsible for batch releaseMillmount Healthcare Ltd.
Block 7
City North Business Campus
Stamullen, Co. Meath K32 YD60
Ireland

Nuvisan GmbH
Wegenerstrasse 13,
89231 Neu-Ulm,
Germany

Nuvisan France SARL
2400, Route des Colles,
06410, Biot,
France
Max shelf life36 months
Storage conditions2°C – 8°C
List of excipientsAcetic acid
Sodium acetate trihydrate
Glycine
Polysorbate 80
Water for injections

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Evidentic offers multiple batches of original drug aliquots in low binding Eppendorf tubes for research use only. We provide licence-free drug aliquots with long, short or even “negative shelf life” by storing the products at recommended temperatures (either 2-8°C or -80°C) and ensuring fully functional molecules for research purposes.

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